Animal Mimicry (hybrid) – The character is a hybrid of a human and an animal.
The Man Wolf (Marvel) is not exactly a werewolf (Marvel Legacy: The 70’s Handbook #1).
Werewolf by Night (Marvel) has a werewolf as the protagonist! A very tough guy summons the courage to fight the werewolf in Werewolf by Night V1 #2.
The Wolf is yet another human/wolf hybrid (Who’s Who in the Impact Universe #2).
The DC Silver Age used established characters as werewolves as recurrent plot device (Action Comics V1 #283, Jimmy Olsen V1 #44, Superboy V1 #116, Superboy V1 #180).
There are too many transgenic superheroes and supervillains to list here that are hybrids. However there are some titles in which hybrid animals are a major theme and they deserve mention.
In Creature Cops Special Varmint Unit, the reader is exposed to an animal control unit the deals with hybrid animals exclusively.
The Creeptures (Impact) are a team of hybrid animals (Who’s Who in the Impact Universe #3).
The Elephantmen (Image) also have human/animal heroes versus human/hybrid villains (Elephantmen #0).
In Teenage Mutant Ninja Turtles the heroes are a human/turtle hybrid and most of the villains are also human/animal hybrids.
The Griffin (Marvel) in Marvel Team-Up v1 #78 provides a good demonstration why the transgenic route is a bad idea for superpowers!
The DC Silver Age had a couple of colorful hybrid animals (House of Mystery V1 #109, House of Secrets V1 #31, Strange Adventures V1 #165)!
A collection of animal-human hybrids in The Unbeatable Squirrel Girl #6 (2016).
Athentia the Great Sphinx – Creature Collection II. Dark Menagerie
Were Vulture – Creature Collection I
Werepanther – TSR 2158 Monstrous Compendium Annual Volume 2
Wereshark – TSR 2158 Monstrous Compendium Annual Volume 2